Stopping is a plan, not an event, and the research on what follows is worth reading before you start. This page covers what happens after, and what the Off-Ramp program in Loopa actually is.
Whether and when to stop is your prescriber's call, not Loopa's.
What the research says happens
In a randomized withdrawal trial, participants who stopped regained a substantial part of the weight they had lost, and cardiometabolic improvements moved back toward baseline (Wilding JPH et al., Diabetes, Obesity and Metabolism, 2022 · doi:10.1111/dom.14725).
A study of people treated for weight recurrence after a sleeve records the same expectation plainly: "weight regain after discontinuation of the medication is highly likely" (Jamal M et al., Obesity Surgery, 2024 · doi:10.1007/s11695-024-07137-0).
That is not an argument for or against stopping. It is the thing to know, so that a change afterwards reads as expected rather than as a personal failure.
Why it happens
The appetite signal the medicine was providing stops. Hunger and food noise return toward where they were. Nothing has gone wrong with you; the input changed.
The 2025 American College of Cardiology consensus guidance covers what follows stopping as part of its treatment framing (Gilbert et al., JACC, 2025 · doi:10.1016/j.jacc.2025.05.024).
What the Off-Ramp program is
A six-week structured program in Loopa for people coming off a GLP-1. It is a habit and tracking framework and it contains no medication guidance of any kind.
What it does:
- Keeps the protein target you had, because the reason for it does not stop when the medicine does
- Keeps the check-in going, including food noise, so a change is visible as it happens rather than in hindsight
- Keeps a training rhythm, which is the other lever on lean mass
- Asks you the same questions each week, so the weeks are comparable
What it does not do: tell you when to stop, how to taper, what to take instead, or whether to restart. Those are all your prescriber's.
The thing worth setting up first
Weigh-ins and check-ins from before you stop. A fortnight of ordinary days on the medicine is the comparison that makes the weeks afterwards mean something, and it cannot be created retrospectively.
Plateaus and what Loopa calls one
Loopa marks a plateau when your seven-day average weight has moved less than a set percentage of body weight over 21 days, with a weight recorded in the last week. It is a description of the chart. The copy on that state contains no failure language, deliberately, and there is a test that enforces it.
How Loopa helps
- Join the program: Health › Protocols › Programs › Off-Ramp.
- Keep the check-in: the food-noise slider stays available through the program.
- Watch the trend, not the day: Progress › Trends.
- Take it to your appointment: Summary for your appointment covers the window either side of a change.
Related
- GLP-1 medicines explained
- Food noise, and how Loopa tracks it
- Protecting muscle while losing weight
- Weight coming back
- Understanding your trends
Where this comes from
Everything on this page is drawn from peer-reviewed research and published consensus guidance, cited above. The full list is at loopahealth.app/sources. Loopa does not give medical advice. It does not decide whether to stop a medicine, does not taper anything and never sets a dose. Your prescriber does.
