'''Stopping is a plan, not an event, and the research on what follows is worth reading before you start.''' This page covers what happens after, and what the Off-Ramp program in Loopa actually is.
'''Whether and when to stop is your prescriber's call, not Loopa's.'''
== What the research says happens ==
In a randomized withdrawal trial, participants who stopped regained a substantial part of the weight they had lost, and cardiometabolic improvements moved back toward baseline (Wilding JPH et al., ''Diabetes, Obesity and Metabolism'', 2022 · [https://doi.org/10.1111/dom.14725 doi:10.1111/dom.14725]).
A study of people treated for weight recurrence after a sleeve records the same expectation plainly: "weight regain after discontinuation of the medication is highly likely" (Jamal M et al., ''Obesity Surgery'', 2024 · [https://doi.org/10.1007/s11695-024-07137-0 doi:10.1007/s11695-024-07137-0]).
That is not an argument for or against stopping. It is the thing to know, so that a change afterwards reads as expected rather than as a personal failure.
== Why it happens ==
The appetite signal the medicine was providing stops. Hunger and food noise return toward where they were. Nothing has gone wrong with you; the input changed.
The 2025 American College of Cardiology consensus guidance covers what follows stopping as part of its treatment framing (Gilbert et al., ''JACC'', 2025 · [https://doi.org/10.1016/j.jacc.2025.05.024 doi:10.1016/j.jacc.2025.05.024]).
== What the Off-Ramp program is ==
A six-week structured program in Loopa for people coming off a GLP-1. It is a habit and tracking framework and it contains no medication guidance of any kind.
What it does:
- Keeps the protein target you had, because the reason for it does not stop when the medicine does
- Keeps the check-in going, including food noise, so a change is visible as it happens rather than in hindsight
- Keeps a training rhythm, which is the other lever on lean mass
- Asks you the same questions each week, so the weeks are comparable
What it does not do: tell you when to stop, how to taper, what to take instead, or whether to restart. Those are all your prescriber's.
== The thing worth setting up first ==
Weigh-ins and check-ins from '''before''' you stop. A fortnight of ordinary days on the medicine is the comparison that makes the weeks afterwards mean something, and it cannot be created retrospectively.
== Plateaus and what Loopa calls one ==
Loopa marks a plateau when your seven-day average weight has moved less than a set percentage of body weight over 21 days, with a weight recorded in the last week. It is a description of the chart. '''The copy on that state contains no failure language''', deliberately, and there is a test that enforces it.
== How Loopa helps ==
- '''Join the program:''' '''Health › Protocols › Programs › Off-Ramp'''.
- '''Keep the check-in:''' the food-noise slider stays available through the program.
- '''Watch the trend, not the day:''' '''Progress › Trends'''.
- '''Take it to your appointment:''' '''Summary for your appointment''' covers the window either side of a change.
== Related ==
- [[glp-1-medications-explained|GLP-1 medicines explained]]
- [[food-noise-and-how-loopa-tracks-it|Food noise, and how Loopa tracks it]]
- [[protecting-muscle-while-losing-weight|Protecting muscle while losing weight]]
- [[weight-recurrence|Weight coming back]]
- [[understanding-your-trends|Understanding your trends]]
== Where this comes from ==
Everything on this page is drawn from peer-reviewed research and published consensus guidance, cited above. The full list is at [https://loopahealth.app/sources/ loopahealth.app/sources]. '''Loopa does not give medical advice.''' It does not decide whether to stop a medicine, does not taper anything and never sets a dose. Your prescriber does.
'''Stopping is a plan, not an event, and the research on what follows is worth reading before you start.''' This page covers what happens after, and what the Off-Ramp program in Loopa actually is. '''Whether and when to stop is your prescriber's call, not Loopa's.''' == What the research says happens == In a randomized withdrawal trial, participants who stopped regained a substantial part of the weight they had lost, and cardiometabolic improvements moved back toward baseline (Wilding JPH et al., ''Diabetes, Obesity and Metabolism'', 2022 · [https://doi.org/10.1111/dom.14725 doi:10.1111/dom.14725]). A study of people treated for weight recurrence after a sleeve records the same expectation plainly: "weight regain after discontinuation of the medication is highly likely" (Jamal M et al., ''Obesity Surgery'', 2024 · [https://doi.org/10.1007/s11695-024-07137-0 doi:10.1007/s11695-024-07137-0]). That is not an argument for or against stopping. It is the thing to know, so that a change afterwards reads as expected rather than as a personal failure. == Why it happens == The appetite signal the medicine was providing stops. Hunger and food noise return toward where they were. Nothing has gone wrong with you; the input changed. The 2025 American College of Cardiology consensus guidance covers what follows stopping as part of its treatment framing (Gilbert et al., ''JACC'', 2025 · [https://doi.org/10.1016/j.jacc.2025.05.024 doi:10.1016/j.jacc.2025.05.024]). == What the Off-Ramp program is == A six-week structured program in Loopa for people coming off a GLP-1. It is a habit and tracking framework and it contains no medication guidance of any kind. What it does: * Keeps the protein target you had, because the reason for it does not stop when the medicine does * Keeps the check-in going, including food noise, so a change is visible as it happens rather than in hindsight * Keeps a training rhythm, which is the other lever on lean mass * Asks you the same questions each week, so the weeks are comparable What it does not do: tell you when to stop, how to taper, what to take instead, or whether to restart. Those are all your prescriber's. == The thing worth setting up first == Weigh-ins and check-ins from '''before''' you stop. A fortnight of ordinary days on the medicine is the comparison that makes the weeks afterwards mean something, and it cannot be created retrospectively. == Plateaus and what Loopa calls one == Loopa marks a plateau when your seven-day average weight has moved less than a set percentage of body weight over 21 days, with a weight recorded in the last week. It is a description of the chart. '''The copy on that state contains no failure language''', deliberately, and there is a test that enforces it. == How Loopa helps == * '''Join the program:''' '''Health › Protocols › Programs › Off-Ramp'''. * '''Keep the check-in:''' the food-noise slider stays available through the program. * '''Watch the trend, not the day:''' '''Progress › Trends'''. * '''Take it to your appointment:''' '''Summary for your appointment''' covers the window either side of a change. == Related == * [[glp-1-medications-explained|GLP-1 medicines explained]] * [[food-noise-and-how-loopa-tracks-it|Food noise, and how Loopa tracks it]] * [[protecting-muscle-while-losing-weight|Protecting muscle while losing weight]] * [[weight-recurrence|Weight coming back]] * [[understanding-your-trends|Understanding your trends]] == Where this comes from == Everything on this page is drawn from peer-reviewed research and published consensus guidance, cited above. The full list is at [https://loopahealth.app/sources/ loopahealth.app/sources]. '''Loopa does not give medical advice.''' It does not decide whether to stop a medicine, does not taper anything and never sets a dose. Your prescriber does.
